Exploration of suitable pharmacodynamic parameters for acarbose bioequivalence evaluation: A series of clinical trials with branded acarbose
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چکیده
منابع مشابه
Pharmacodynamic comparison of two formulations of Acarbose 100-mg tablets.
WHAT IS KNOWN AND OBJECTIVE Acarbose, an α-glycosidase inhibitor, is used to treat diabetic patients. Pharmacokinetic evaluation of acarbose is difficult because <2% is absorbed systemically. The current investigation evaluated the bioequivalence of two formulations of acarbose through pharmacodynamic comparison. METHODS This investigation consisted of a pilot study and a main study. The pilo...
متن کاملEvaluation of Clinical Trials
In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
متن کاملAcarbose and postprandial hypotension.
Acarbose and Postprandial Hypotension To the Editor: We read with interest the article by Shibao et al,1 who reported that acute administration of acarbose had a substantial, beneficial effect on the hypotensive response to a high-carbohydrate meal in patients with autonomic failure. It was suggested that this effect is mediated, at least in part, by a reduction in the insulinemic response to a...
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با توجه به تجزیه و تحلیل داده ها ما دریافتیم که سطح درامد و تعداد نمایندگیها باتقاضای بیمه عمر رابطه مستقیم دارند و نرخ بهره و بار تکفل با تقاضای بیمه عمر رابطه عکس دارند
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2020
ISSN: 0306-5251,1365-2125
DOI: 10.1111/bcp.14324